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Orthopedic device design and new materials are continuously being developed to overcome limitations that exist with current bone tissue regrowth strategies. Traditional efforts have been made to induce osteogenic differentiation of mesenchymal stem cells directly by generating biocompatible or biologically “inert” substrate surfaces. Unfortunately, most developers have failed to apply strategies that address protein adsorption and immune cell response as it pertains to bone dynamics.
This paper reviews how the immune system adversely impacts biocompatible implants and how Implant Surfaces uses immunological modulation design to develop immunocompatible and immuno-optimized surfaces by focusing on the development of a surface for osteoblasts and their attachment to and proliferation on orthopedic implant materials to eliminate or significantly reduce the causes of implant fixation failure. It also highlights select research that led to the development and choice of what would become the IntimateBondTM Osteoblast surface, now implanted in well over 50,000 surgeries.
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